現(xiàn)貨moradec AH-101-AF說(shuō)明書
αHFc NC MMAF
抗人IgG Fc MMAF抗體與不可裂解連接子
目錄號(hào)：AH-101-AF
αHFc NC MMAF是一種抗人IgG Fc特異性抗體，其與單甲基auristatin F（MMAF）結(jié)合，具有不可裂解的接頭。抗體部分是對(duì)人IgG的Fc區(qū)特異的多克隆抗體。單甲基auristatin F（MMAF）是一種細(xì)胞毒性小分子，通過(guò)阻斷微管蛋白的聚合來(lái)抑制細(xì)胞分裂。連接MMAF和抗體的不可裂解接頭在細(xì)胞外液中是穩(wěn)定的，但在進(jìn)入細(xì)胞時(shí)可以通過(guò)未指明的機(jī)制裂解。
| Anti-human IgG Fc-MMAF Antibody with Non-Cleavable Linker | Catalog Number: AH-101-AF |
| αHFc-NC-MMAF is anti-human IgG Fc specific antibody conjugated to monomethyl auristatin F (MMAF) with a non-cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. Monomethyl auristatin F (MMAF) is a cytotoxic small molecule which inhibits cell division by blocking the polymerization of tubulin. The non-cleavable linker connecting MMAF to the antibody is stable in extracellular fluid, but can be cleaved by unspecified mechanisms upon entering cells. | |
