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      lifediagnostics授權代理——上海起發

       更新時間:2024-04-03 點擊量:401

      lifediagnostics

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      鏈接:https://lifediagnostics.com

      Life Diagnostics生產ELISA試劑盒、SPARCL™試劑盒用于臨床前研究和獸醫診斷的純化生物標志物和抗體。Life Diagnostics的專業領域包括心血管、急性期、免疫毒性和免疫學生物標志物,涉及的物種包括老鼠、大鼠、兔子、貓、狗、豬、牛、猴子和雞。此外,Life Diagnostics還開發了抗PEG單克隆抗體和ELISA試劑盒,用于檢測PEG、mPEG化蛋白和抗PEG抗體。Life Diagnostics公司一直致力于為客戶提供高質量的產品和優質的服務,贏得了廣泛的贊譽和信任。

      主要產品線

      一、SPARCL試劑盒

      SPARCL™(空間近距分析試劑捕獲發光)檢測使用兩種特定的抗體;一種與HRP結合,另一種與二氫化吖啶結合,一種化學發光底物。當HRP和二氫化吖啶結合的抗體與它們的靶生物標志物結合時,加入過氧化氫(觸發溶液)后,HRP催化氧化鄰近二氫化吖啶分子,導致與生物標志物濃度成比例的化學發光。遠離HRP的二氫化吖啶分子不被氧化,因此不產生發光。這一原理可以開發一系列快速敏感的均相免疫分析方法。

      典型的SPARCL™檢測不需要洗滌步驟,只需一次孵育,從開始到結束大約需要45分鐘。ELISA需要1-4次孵育,1-3次洗滌步驟,需要2-4+小時。SPARCL™試劑盒需要一個能夠同時加樣和測量的光度計。Life Diagnostics提供一系列的SPARCL™檢測試劑盒。

      SPARCLELISA的優秀替代品

      –簡單發光免疫測定

      –單次培養30分鐘

      –無清洗步驟

      –高靈敏度

      –高吞吐量

      參考文獻

      1.Baka R, et al. Quantitative proteomics of cerebrospinal fluid using tandem mass tags in dogs with recurrent epileptic sezures. J Proteomics 231:1039777 (2021)

      2.Kules J, et al. The plasma proteome and the acute phase protein response in canine pyometra. J Proteomics 223:103817 (2020)

      3.Liu M, et al. Cardiovascular-renal axis disorder and the acute-phase proteins in cats with congestive heart failure caused by primary cardiomyopathy. J Vet Intern Med. 34(3):1078-1090 (2020)

      4.Dalanezi FM, et al. Concentrations of acute phase proteins in milk from cows with clinical mastitis caused by different pathogens. Pathogens 9(9):706 (2020)

      5.Boulay I, et.al. SPARCL™: Use of a novel technology in validation of a Non-human primate and rat cardiac troponin-I assay in serum. CiToxLAB, 2016

      6.Boulay I, et.al. SPARCL™: Use of a Novel Technology in Validation of a Non-Human Primate C-Reactive Protein Assay in Serum. CiToxLAB. 2016

      部分產品信息

      貨號

      產品名稱

      規格

      AFP-SP-4

      Dog Alpha-fetoprotein

      96-well

      AGP-SP-11

      Cow AGP

      96-well

      AGP-SP-2

      Rat AGP

      96-well

      AGP-SP-5

      Chicken AGP

      96-well

      AGP-SP-8

      Cat AGP

      96-well

      CER-SP-4

      Dog Ceruloplasmin

      96-well

      CYSC-SP-2

      Rat Cystatin-C

      96-well

      HFABP-SP-20

      Human H-FABP

      96-well

      IGG1-SP-1

      Mouse IgG1

      96-well

      IGG-SP-1

      Mouse IgG

      96-well

      MPEG-SP

      mPEG

      96-well

      MYO-SP-1

      Mouse Myoglobin

      96-well

      MYO-SP-2

      Rat Myoglobin

      96-well

      MYO-SP-3

      Monkey Myoglobin

      96-well

      PEG-SP

      PEG

      96-well

      TK1-SP-20

      Human Thymidine Kinase 1

      96-well

      二、ELISA試劑盒

      KLH、抗SRBC、抗破傷風毒素、抗DNP和抗TNPIgMIgG被用作免疫毒性的生物標志物。Life Diagnostics為小鼠、大鼠、雞、猴子和人類生產這些生物標志物的ELISA試劑盒。

      使用Life Diagnostics ELISA試劑盒發表的部分文獻

      1.Lo J, et al. Immature dendritic cell therapy confers durable immune modulation in an antigen-dependent and antigen-independent manner in nonobese diabetic mice. Journal of Immunology Research. Volume 2018 Article ID 5463879 (2108) [Mouse anti-KLH IgG & IgM]

      2.Ksiazek A and Konarzewski M. Heat dissipation does not suppress an immune response in laboratory mice divergently selected for basal metabolic rate (BMR). Journal of Experimental Biology. 219:1542-1551 (2016) [Mouse anti-KLH IgG & IgM]

      3.Tan X, et al. Immunotoxicological evaluation of genetically modified rice expressing Cry1Ab/AcProtein (TT51-1) by a 6-month feeding study on cynomolgus monkeys. PLoSONE 11(9):e0163879.doi:10.1371/journal.pone.0163879 (2016) [Monkey anti-KLH IgG & IgM]

      4.Ma H, Wan S, and Xia C-Q. Immunosuppressive CD11b+Ly6Chi monocytes in pristane-induced lupus mouse model. Journal of Leukocyte Biology 99:1121 (2016). [Mouse anti-KLH IgG]

      5.Nixon AE, et al. Fully human monoclonal antibody inhibitors of the neonatal Fc receptor reduce circulating IgG in non-human primates. Frontiers in Immunology. Volume 6, Article 176. (2015) [Monkey anti-tetanus toxoid & anti-KLH IgG & IgM]

      6.Bernett MJ, et al. Immune suppression in cynomolgus monkeys by XPro9523. (2013) https://doi.org/10.4161/mabs.23976 [Monkey anti-KLH IgG & IgM]

      7.Nain S and Smits JEG. Pathological, immunological and biochemical markers of subchronic arsenic toxicity in rats. Environmental Toxicology. (2010) http://onlinelibrary.wiley.com/doi/10.1002/tox.20635/abstract [Rat anti-KLH IgG & IgM]

      8.Betz BC, Jordan-Williams KL, Wang C, Kang SG, Liao J, Logan MR, Kim CH and Taparowsky EJ. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J. Exp. Med. 207(5):933-942 (2011) [Mouse anti-SRBC IgG & IgM] http://jem.rupress.org/content/207/5/933.full.pdf+html

      9.Schaffer BS, Grayson MH and Wortham JM, et al. Immune competency of a hairless mouse strain for improved preclinical studies in genetically engineered mice. Mol. Cancer Ther. 9:2354-2364 (2010) [Mouse anti-KLH IgG & IgM] http://mct.aacrjournals.org/content/9/8/2354.full.pdf+html

      10.Efanov A, Zanesi N, NazaryanN, Santanam U, Palmarchuck A Croce CM and Pekarsky Y. CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Leukemia 24:970-975 (2010) [Mouse anti-SRBC IgM]

      部分產品信息

      貨號

      產品名稱

      規格

      KLHG-1

      Mouse Anti-KLH IgG ELISA

      96-well

      KLHM-1

      Mouse Anti-KLH IgM ELISA

      96-well

      KLHG-20

      Human Anti-KLH IgG ELISA

      96-well

      KLHM-20

      Human Anti-KLH IgM ELISA

      96-well

      TTG-2

      Rat Anti-Tetanus Toxoid IgG ELISA

      96-well

      TTM-2

      Rat Anti-Tetanus Toxoid IgM ELISA

      96-well

      DNPG-1

      Mouse Anti-DNP IgG ELISA

      96-well

      DNPM-1

      Mouse Anti-DNP IgM ELISA

      96-well

      TNPG-1

      Mouse Anti-TNP IgG ELISA

      96-well

      TNPM-1

      Mouse Anti-TNP IgM ELISA

      96-well

      SRBCG-5

      Chicken Anti-SRBC IgG ELISA

      96-well

      SRBCM-5

      Chicken Anti-SRBC IgM ELISA

      96-well

      三、蛋白

      Life Diagnostics提供alpha-1-acid glycoproteinCRP、haptoglobin、SAA急性期生物標志物troponin-I、myoglobin、FABP等心血管生物標志物免疫球蛋白、Haptoglobin、Gc-Globulin肝臟生物標志物、Troponin-I骨骼肌生物標志物等系列產品,用于臨床前研究研究和診斷分析開發。

      部分產品信息

      貨號

      產品名稱

      規格

      8340

      Bovine (Cow) alpha-1-acid glycoprotein

      1 mg

      9060

      CAT LRG1

      100 μg

      8160

      Cat Haptoglobin

      1 mg

      EXFABP-5-0.05

      Chicken EX-FABP

      0.05 mg

      9005

      Dog Serum Amyloid A (SAA)

      0.1 mg

      8356

      Rabbit a-1-Acid glycoprotein

      0.1 mg

      20110

      Mouse L-FABP

      0.1 mg

      20220

      Rat Gc-Globulin

      0.1 mg

      HAPT-2

      Rat Haptoglobin

      1 mg

      3610

      Chicken Skeletal Muscle Troponin-I

      0.1 mg

      3410

      Sheep Skeletal Muscle Troponin-I

      0.1 mg

      四、PEG相關產品

      聚乙二醇(PEG)鏈連接到治療性抗體和酶上,可以增加生物制劑的循環半衰期。Life Diagnostics生產單克隆抗體和ELISA試劑盒,用于檢測PEG和甲氧基-PEG化蛋白。此外,Life Diagnostics還提供用于檢測小鼠、大鼠和猴子體內抗PEG IgGIgMELISA試劑盒。

      部分產品信息

      貨號

      產品名稱

      規格

      5D6-3

      Anti-methoxy-PEG Monoclonal, Clone 5D6-3

      100 μg

      1D9-6

      Anti-PEG Monoclonal, Clone 1D9-6

      100 μg

      PEGPAB-01

      Anti-PEG Rabbit Polyclonal IgG Antibody

      100 μg

      PEGM-3

      Monkey Anti-PEG IgM ELISA

      96-well

      PEGM-20

      Human Anti-PEG IgM ELISA

      96-well

      PEGM-10

      Rabbit Anti-PEG IgM ELISA

      96-well

      PEGG-3

      Monkey Anti-PEG IgG ELISA

      96-well

      PEGG-20

      Human Anti-PEG IgG ELISA

      96-well

      PEGG-10

      Rabbit Anti-PEG IgG ELISA

      96-well

      PEGM-2

      Rat Anti-PEG IgM ELISA

      96-well

      PEGM-1

      Mouse Anti-PEG IgM ELISA

      96-well

      PBSA-00

      Multi PEGylated BSA

      1 mg

      PBSA-01P

      Mono-PEGylated BSA (pentanoic acid-PEG, 20 kDa)

      100 μg

      五、抗體

      Life Diagnostics提供alpha-1-acid glycoprotein急性期生物標志物、troponin-I、myoglobin、FABP等心血管生物標志物免疫球蛋白Haptoglobin、Gc-Globulin肝臟生物標志物、Troponin-I骨骼肌生物標志物等蛋白抗體以及一系列二抗產品。

      部分產品信息

      貨號

      產品名稱

      規格

      IGE-4-13H5

      Anti-Dog IgE Monoclonal

      1 mg

      IGE-4-4D1

      Anti-Dog IgE Monoclonal

      1 mg

      IGM-23-12B9

      Anti-Trout IgM Monoclonal

      1 mg

      IGM-23-2E7

      Anti-Trout IgM Monoclonal

      1 mg

      10C2-9

      Monoclonal Anti Monkey IgG

      1 mg

      6D11-2

      Monoclonal Anti Monkey IgG

      1 mg

      2C11-1-5

      Monoclonal Anti Monkey IgM

      1 mg

      7E8-1-13

      Monoclonal Anti Monkey IgM

      1 mg

      AGP-08-4F57

      Anti-cat alpha-1-acid glycoprotein

      1 mg

      下圖為Life Diagnostics公司授權上海起發作為中國區域代理的授權書。

      Life Diagnostics熱賣產品

      貨號

      產品名稱

      規格

      品牌

      CRP-3

      Monkey C-Reactive Protein (CRP) ELISA kit

      96 well

      Life Diagnostics

      KLHM-3

      Monkey Anti-KLH IgM ELISA kit

      96 well

      Life Diagnostics

      KLHG-3-INT

      Monkey Anti-KLH IgG ELISA kit for export

      96 well

      Life Diagnostics

      KLHM-2

      RAT ANTI-KLH IGM ELISA

      96 well

      Life Diagnostics

      KLHG-2

      Rat Anti-KLH IgG ELISA

      96 well

      Life Diagnostics

      1D9-6/MG

      ANTI-PEG MONOCLONAL, CLONE 1D9-6

      0.1mg

      Life Diagnostics

      PEGG-20

      HUMAN ANTI-PEG IGG ELISA

      96 well

      Life Diagnostics

      IGG-20

      Human IgG ELISA

      96 well

      Life Diagnostics

      5H4-2-1mg

      ANTI-METHOXY PEG

      1 mg

      Life Diagnostics

      1D9-6-1mg

      ANTI-PEG MONOCLONAL, CLONE

      1 mg

      Life Diagnostics

      PBSA-00

      Multi PEGylated BSA - BSA with multiple covalently attached 20 kDa mPEG chains

      1 mg

      Life Diagnostics

      PBAS-00-550-1mg

      Multi PEGylated BSA

      1 mg

      Life Diagnostics

      PBAS-00-550-10mg

      Multi PEGylated BSA

      10 mg

      Life Diagnostics

      5D6-3-0.1mg

      ANTI-METHOXY PEG

      0.1 mg

      Life Diagnostics

      KLHM-20

      HUMAN ANTI-KLH IGM ELISA

      96 well

      Life Diagnostics

      5D6-3-1mg

      ANTI-METHOXY PEG

      1 mg

      Life Diagnostics

      5H4-2-0.1mg

      ANTI-METHOXY PEG

      0.1 mg

      Life Diagnostics

      KLHG-20

      Human Anti-KLH IgG ELISA

      96 well

      Life Diagnostics

      CLUS-1

      Mouse Clusterin ELISA kit

      96 well

      Life Diagnostics

      8511-0.1mg

      Rat a-2-Macroglobulin

      0.1 mg

      Life Diagnostics

      IGE-3

      MONKEY IGE ELISA

      96 well

      Life Diagnostics

      IGE-2

      Rat IgE

      96 well

      Life Diagnostics

      CTNI-3-US

      MONKEY CARDIAC TROPONIN-I ELISA

      96 well

      Life Diagnostics

      CTNI-1-US

      Mouse cTnI, (serum/plasma) ELISA kit

      96 well

      Life Diagnostics

      CTNI-1-HS

      Mouse cTnI (serum) ELISA kit

      96 well

      Life Diagnostics

      crp-sp-20

      HUMAN CRP SPARCL™ ASSAY

      96 well

      Life Diagnostics

      CRP-2

      Rat C-Reactive Protein (CRP) ELISA kit

      96 well

      Life Diagnostics

      8511-PT1MG

      RAT ALPHA-2-MACROGLOBULIN, 8511

      0.1 mg

      Life Diagnostics




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